Endocrine Abstracts

Background: Cushing’s syndrome (10-15/million people diagnosed/year) is quite rare with Cushing’s disease accounting for >70% of cases in adults. Spinal epidural lipomatosis (SEl) secondary to endogenous Cushing’s syndrome is even more rare condition (8 reported cases so far) of which 3 cases are secondary to Cushing’s disease. Here, we highlight a case of ACTH-dependent Cushing disease with resultant spinal epidural lipomatosis (SEl) that was treated w...

Introduction: Pituitary apoplexy (PA) is a rare endocrine emergency with less described entity being its subacute/non-acute presentation. Incidence of PA is difficult to determine, varying 2%-12% of pituitary adenoma. Hypopituitarism in PA is observed in up to 70% of cases with diabetes Insipidus (DI) observed in <5% of cases and mostly transient.Case description: 82-year old female with pituitary macroprolactinoma (1.5 cm) presented with 3-week hist...

Background: Cushing’s syndrome is rare (1.8-3.2 cases/million population)1, with Cushing’s disease (CD) accounting >70%. We seek to highlight a rare complication, spinal epidural lipomatosis (SEL), rare cause of spinal compression (prevalence-2.5%2), commonly related to exogenous steroid use with 3 reported cases secondary to CD3,4,5.Case: 36-years old man, background asthma and alcohol excess presented wit...

Background: Carbimazole is a commonly used and effective treatment for hyperthyroidism. Although on the World Health Organisation’s list of essential medicines, it comes with the potentially significant side effect of agranulocytosis. We set out a Quality Improvement Project to improve communication with patients to ensure their understanding through creating a patient information leaflet.Methods: 30 patients receiv...

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

Aim: To assess side effects of testosterone (TRT).Introduction: TRT in men with hypogonadism helps improve libido, erectile dysfunction, energy levels and bone density. However the risks/benefits of TRT in terms of ischemic heart disease (IHD), stroke and venous thromboembolism (VTE) is controversial no definitive answers from current evidence. We evaluated the side effects of TRT in patients attending endocrinology outpatient clinic between 2009 to 2019...

Aim: To compare efficacy of different formulations of TRT in treatment of hypogonadismBackground: Different formulations of testosterone are available for treatment of hypogonadism in men. TRT improves libido, sexual function, bone density and general well-being. We analysed data of 106 patients on TRT to compare efficacy of topical and injectable formulations.Methods: It’s a retrospective data analysis of 106 patient receivin...